Acute panmyelosis with myelofibrosis ( APMF) it is a poorly defined disorder that arises as either a clonal disorder, or following toxic exposure to the bone marrow.
Signs and symptoms [ edit ]
Bone marrow biopsy shows abnormal
megakaryocytes, macrocytic erythropoiesis, and defects in neutrophil production and fibrosis of the marrow (myelofibrosis).
Clinically patients present with reduction in the count of all blood cells (
pancytopenia), a very few blasts in the peripheral blood and no or little spleen enlargement ( splenomegaly).
Cells are usually
Prognosis and treatment [ edit ]
Median survival is about 9 months.
Autologous stem cell transplantation has been used in treatment.
Terminology [ edit ]
Controversy remains today whether this disorder is a subtype of
acute myeloid leukemia or myelodysplastic syndromes; however, it is currently classified as a form of AML. 
See also [ edit ]
References [ edit ]
Hoffman R, Benz E, Shattil S, Furie B, Cohen H (2004). Hematology: Basic Principles and Practice (4th ed.). Churchill Livingstone.
Orazi A, O'Malley DP, Jiang J, et al. (May 2005). "Acute panmyelosis with myelofibrosis: an entity distinct from acute megakaryoblastic leukemia". Mod. Pathol. 18 (5): 603–14. doi: . 10.1038/modpathol.3800348 PMID 15578075.
Ngirabacu MC, Ravoet C, Dargent JL, et al. (December 2006). "Long-term follow-up of autologous peripheral blood stem cell transplantation in the treatment of a patient with acute panmyelosis with myelofibrosis". Haematologica. 91 (12 Suppl): ECR53. PMID 17194659.
Thiele J, Kvasnicka HM, Schmitt-Graeff A (April 2004). "Acute panmyelosis with myelofibrosis". Leuk. Lymphoma. 45 (4): 681–7. doi: 10.1080/10428190310001625692. PMID 15160939.
Thiele J, Kvasnicka HM, Zerhusen G, et al. (August 2004). "Acute panmyelosis with myelofibrosis: a clinicopathological study on 46 patients including histochemistry of bone marrow biopsies and follow-up". Ann. Hematol. 83 (8): 513–21. doi: 10.1007/s00277-004-0881-8. PMID 15173958.
See also [ edit ]
External links [ edit ]