Lipid A acylase

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Antimicrobial peptide resistance and lipid A acylation protein PagP
1thq opm.png
Identifiers
SymbolPagP
PfamPF07017
InterProIPR009746
OPM superfamily237
OPM protein3gp6

Antimicrobial peptide resistance and lipid A acylation protein PagP is a family of several bacterial antimicrobial peptide resistance and lipid A acylation (PagP) proteins. The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic antimicrobial peptides produced during the host innate immune response.

References[edit]

Hwang PM, Choy WY, Lo EI, Chen L, Forman-Kay JD, Raetz CR, Privé GG, Bishop RE, Kay LE (October 2002). "Solution structure and dynamics of the outer membrane enzyme PagP by NMR". Proceedings of the National Academy of Sciences of the United States of America. 99 (21): 13560–5. Bibcode:2002PNAS...9913560H. doi:10.1073/pnas.212344499. PMC 129713. PMID 12357033.