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Monoclonal antibody
Clinical data
Other namesAnti-LINGO-1
Legal status
Legal status
  • Investigational
CAS Number

BIIB033 (also known as Anti-LINGO-1) is a monoclonal antibody targeting LINGO1. As of 2015 it was being developed by Biogen as a treatment for diseases such as multiple sclerosis and optic neuritis.[1][2][3]

See also[edit]


  1. ^ "Biogen MS Drug Results Are 'Mildly Encouraging' In Eye Disease Test". Forbes. Retrieved 2015-10-13.
  2. ^ Clinical trial number NCT01864148 for "Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of BIIB033 in Participants With Relapsing Forms of Multiple Sclerosis When Used Concurrently With Avonex" at
  3. ^ Tran JQ, Rana J, Barkhof F, Melamed I, Gevorkyan H, Wattjes MP, et al. (August 2014). "Randomized phase I trials of the safety/tolerability of anti-LINGO-1 monoclonal antibody BIIB033". Neurology. 1 (2): e18. doi:10.1212/NXI.0000000000000018. PMC 4202679. PMID 25340070.