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Protein BTLA PDB 2aw2.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesBTLA, BTLA1, CD272, B and T lymphocyte associated
External IDsOMIM: 607925 MGI: 2658978 HomoloGene: 52233 GeneCards: BTLA
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for BTLA
Genomic location for BTLA
Band3q13.2Start112,463,966 bp[1]
End112,499,472 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 112.46 – 112.5 MbChr 16: 45.22 – 45.26 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

B- and T-lymphocyte attenuator is a protein that in humans is encoded by the BTLA gene.[5][6] BTLA has also been designated as CD272 (cluster of differentiation 272).


BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4.[6] However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a ligand for tumour necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.

Clinical significance[edit]

BTLA activation inhibits the function of human CD8+ cancer-specific T cells.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186265 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052013 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM (July 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776. S2CID 11943145.
  6. ^ a b "Entrez Gene: BTLA B and T lymphocyte associated".
  7. ^ Derré L, Rivals JP, Jandus C, Pastor S, Rimoldi D, Romero P, Michielin O, Olive D, Speiser DE (January 2010). "BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination". The Journal of Clinical Investigation. 120 (1): 157–67. doi:10.1172/JCI40070. PMC 2799219. PMID 20038811. Lay summaryGenetic Engineering & Biotechnology News.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.