Brain implants, often referred to as neural implants, are technological devices that connect directly to a biological subject's brain – usually placed on the surface of the brain, or attached to the brain's cortex. A common purpose of modern brain implants and the focus of much current research is establishing a biomedical prosthesis circumventing areas in the brain that have become dysfunctional after a stroke or other head injuries. This includes sensory substitution, e.g., in vision. Other brain implants are used in animal experiments simply to record brain activity for scientific reasons. Some brain implants involve creating interfaces between neural systems and computer chips. This work is part of a wider research field called brain-computer interfaces. (Brain-computer interface research also includes technology such as EEG arrays that allow interface between mind and machine but do not require direct implantation of a device.)
Neural implants such as deep brain stimulation and Vagus nerve stimulation are increasingly becoming routine for patients with Parkinson's disease and clinical depression, respectively.
Brain implants electrically stimulate, block or record (or both record and stimulate simultaneously) signals from single neurons or groups of neurons (biological neural networks) in the brain. The blocking technique is called intra-abdominal vagal blocking. This can only be done where the functional associations of these neurons are approximately known. Because of the complexity of neural processing and the lack of access to action potential related signals using neuroimaging techniques, the application of brain implants has been seriously limited until recent advances in neurophysiology and computer processing power. Much research is also being done on the surface chemistry of neural implants in effort to design products which minimize all negative effects that an active implant can have on the brain, and that the body can have on the function of the implant. Researchers are also exploring a range of delivery systems, such as using veins, to deliver these implants without brain surgery; by leaving the skull sealed shut, patients could receive their neural implants without running as great a risk of seizures, strokes, or permanent neural impairments, all of which can be caused by open-brain surgery.
Research and applications
Research in sensory substitution has made significant progress since 1970. Especially in vision, due to the knowledge of the working of the visual system, eye implants (often involving some brain implants or monitoring) have been applied with demonstrated success. For hearing, cochlear implants are used to stimulate the auditory nerve directly. The vestibulocochlear nerve is part of the peripheral nervous system, but the interface is similar to that of true brain implants.
Multiple projects have demonstrated success at recording from the brains of animals for long periods of time. As early as 1976, researchers at the NIH led by Edward Schmidt made action potential recordings of signals from rhesus monkey motor cortexes using immovable "hatpin" electrodes, including recording from single neurons for over 30 days, and consistent recordings for greater than three years from the best electrodes.
The "hatpin" electrodes were made of pure iridium and insulated with Parylene, materials that are currently used in the Cyberkinetics implementation of the Utah array. These same electrodes, or derivations thereof using the same biocompatible electrode materials, are currently used in visual prosthetics laboratories, laboratories studying the neural basis of learning, and motor prosthetics approaches other than the Cyberkinetics probes.
Breakthroughs include: studies of the process of functional brain re-wiring throughout the learning of a sensory discrimination, control of physical devices by rat brains, monkeys over robotic arms, remote control of mechanical devices by monkeys and humans, remote control over the movements of roaches, the first reported use of the Utah Array in a human for bidirectional signalling. Currently a number of groups are conducting preliminary motor prosthetic implants in humans. These studies are presently limited to several months by the longevity of the implants. The array now forms the sensor component of the Braingate.
Much research is also being done on the surface chemistry of neural implants in effort to design products which minimize all negative effects that an active implant can have on the brain, and that the body can have on the function of the implant.
Another type of neural implant that is being experimented on is Prosthetic Neuronal Memory Silicon Chips, which imitate the signal processing done by functioning neurons that allows peoples' brains to create long-term memories.
In 2016, scientists out of the University of Melbourne published proof-of-concept data related to a discovery for Stentrode, a device implanted via the jugular vein, demonstrated the potential for a neural recording device to be engineered onto a stent and implanted into a blood vessel in the brain, without the need for open brain surgery. The technology platform is being developed for patients with paralysis to facilitate control of external devices such as robotic limbs, computers and exoskeletons by translating brain activity. It may ultimately help diagnose and treat a range of brain pathologies, such as epilepsy and Parkinson’s disease.
DARPA has announced its interest in developing "cyborg insects" to transmit data from sensors implanted into the insect during the pupal stage. The insect's motion would be controlled from a Micro-Electro-Mechanical System (MEMS) and could conceivably survey an environment or detect explosives and gas. Similarly, DARPA is developing a neural implant to remotely control the movement of sharks. The shark's unique senses would then be exploited to provide data feedback in relation to enemy ship movement or underwater explosives.
In 2006, researchers at Cornell University invented a new surgical procedure to implant artificial structures into insects during their metamorphic development. The first insect cyborgs, moths with integrated electronics in their thorax, were demonstrated by the same researchers. The initial success of the techniques has resulted in increased research and the creation of a program called Hybrid-Insect-MEMS, HI-MEMS. Its goal, according to DARPA's Microsystems Technology Office, is to develop "tightly coupled machine-insect interfaces by placing micro-mechanical systems inside the insects during the early stages of metamorphosis".
The use of neural implants has recently been attempted, with success, on cockroaches. Surgically applied electrodes were put on the insect, which were remotely controlled by a human. The results, although sometimes different, basically showed that the cockroach could be controlled by the impulses it received through the electrodes. DARPA is now funding this research because of its obvious beneficial applications to the military and other areas
In 2009 at the Institute of Electrical and Electronics Engineers (IEEE) Micro-electronic mechanical systems (MEMS) conference in Italy, researchers demonstrated the first "wireless" flying-beetle cyborg. Engineers at the University of California at Berkeley pioneered the design of a "remote controlled beetle", funded by the DARPA HI-MEMS Program. This was followed later that year by the demonstration of wireless control of a "lift-assisted" moth-cyborg.
Eventually researchers plan to develop HI-MEMS for dragonflies, bees, rats and pigeons. For the HI-MEMS cybernetic bug to be considered a success, it must fly 100 metres (330 ft) from a starting point, guided via computer into a controlled landing within 5 metres (16 ft) of a specific end point. Once landed, the cybernetic bug must remain in place.
In 2012, DARPA provided seed funding to Dr. Thomas Oxley, a neurointerventionist at Mount Sinai Hospital in New York City, for a technology that became known as Stentrode. Oxley’s group in Australia was the only non-US-based funded by DARPA as part of the Reliable Neural Interface Technology (RE-NET) program. This technology is the first to attempt to provide neural implants through a minimally invasive surgical procedure that does not require cutting into the skull. That is, an electrode array built onto a self-expanding stent, implanted into the brain via cerebral angiography. This pathway can provide safe, easy access and capture a strong signal for a number of indications beyond addressing paralysis, and is currently in clinical trials in patients with severe paralysis seeking to regain the ability to communicate.
In 2015 it was reported that scientists from the Perception and Recognition Neuro-technologies Laboratory at the Southern Federal University in Rostov-on-Don suggested using rats with microchips planted in their brains to detect explosive devices.
In 2016 it was reported that American engineers are developing a system that would transform locusts into "remote controlled explosive detectors" with electrodes in their brains beaming information about dangerous substances back to their operators.
Current brain implants are made from a variety of materials such as tungsten, silicon, platinum-iridium, or even stainless steel. Future brain implants may make use of more exotic materials such as nanoscale carbon fibers (nanotubes), and polycarbonate urethane.
Brain implants are also being explored by DARPA as part of the Reliable Neural-Interface Technology (RE-NET) program launched in 2010 to directly address the need for high-performance neural interfaces to control the dexterous functions made possible by DARPA’s advanced prosthetic limbs. The goal is to provide high-bandwidth, intuitive control interface for these limbs, in order to achieve their full potential to improve quality of life for wounded troops.
In 1870, Eduard Hitzig and Gustav Fritsch demonstrated that electrical stimulation of the brains of dogs could produce movements. Robert Bartholow showed the same to be true for humans in 1874. By the start of the 20th century, Fedor Krause began to systematically map human brain areas, using patients that had undergone brain surgery.
Yale University physiologist Jose Delgado demonstrated limited control of animal and human subjects' behaviours using electronic stimulation. He invented the stimoceiver or transdermal stimulator, a device implanted in the brain to transmit electrical impulses that modify basic behaviours such as aggression or sensations of pleasure.
Delgado was later to write a popular book on mind control, called Physical Control of the Mind, where he stated: "the feasibility of remote control of activities in several species of animals has been demonstrated [...] The ultimate objective of this research is to provide an understanding of the mechanisms involved in the directional control of animals and to provide practical systems suitable for human application."
In the 1950s, the CIA also funded research into mind control techniques, through programs such as MKULTRA. Perhaps because he received funding for some research through the US Office of Naval Research, it has been suggested (but not proven) that Delgado also received backing through the CIA. He denied this claim in a 2005 article in Scientific American describing it only as a speculation by conspiracy-theorists. He stated that his research was only progressively scientifically motivated to understand how the brain works.
Recent advances in neurotechnologies and neuroimaging, along with an increased understanding of neurocircuitry, are factors contributing to the rapid rise in the use of neurostimulation therapies to treat an increasingly wide range of neurologic and psychiatric disorders. Electrical stimulation technologies are evolving after remaining fairly stagnant for the past 30 years, moving toward potential closed-loop therapeutic control systems with the ability to deliver stimulation with higher spatial resolution to provide continuous customized neuromodulation for optimal clinical outcomes.
Concerns and ethical considerations
Ethical questions raised include who are good candidates to receive neural implants and what are good and bad uses of neural implants. Whilst deep brain stimulation is increasingly becoming routine for patients with Parkinson's disease, there may be some behavioural side effects. Reports in the literature describe the possibility of apathy, hallucinations, compulsive gambling, hypersexuality, cognitive dysfunction, and depression. However, these may be temporary and related to correct placement and calibration of the stimulator and so are potentially reversible.
Some transhumanists, such as Raymond Kurzweil and Kevin Warwick, see brain implants as part of a next step for humans in progress and evolution, whereas others, especially bioconservatives, view them as unnatural, with humankind losing essential human qualities. It raises controversy similar to other forms of human enhancement. For instance, it is argued that implants would technically change people into cybernetic organisms (cyborgs). It's also expected that all research will comply to the Declaration of Helsinki. Yet further, the usual legal duties apply such as information to the person wearing implants and that the implants are voluntary, with (very) few exceptions.
Other concerns involve vulnerabilities of neural implants to cybercrime or intrusive surveillance as neural implants could be hacked, misused or misdesigned.
Sadja states that "one's private thoughts are important to protect" and doesn't consider it a good idea to just charge the government or any company with protecting them. Walter Glannon, a neuroethicist of the University of Calgary notes that "there is a risk of the microchips being hacked by third parties" and that "this could interfere with the user's intention to perform actions, violate privacy by extracting information from the chip".
In fiction and philosophy
Brain implants are now part of modern culture but there were early philosophical references of relevance as far back as René Descartes.
In his 1641 Meditations, Descartes argued that it would be impossible to tell if all one's apparently real experiences were in fact being produced by an evil demon intent on deception. A modern twist on Descartes' argument is provided by the "brain in a vat" thought experiment, which imagines a brain, sustained apart from its body in a vat of nutrients, and hooked up to a computer which is capable of stimulating it in such a way as to produce the illusion that everything is normal.
Popular science fiction discussing brain implants and mind control became widespread in the 20th century, often with a dystopian outlook. Literature in the 1970s delved into the topic, including The Terminal Man by Michael Crichton, where a man suffering from brain damage receives an experimental surgical brain implant designed to prevent seizures, which he abuses by triggering for pleasure. Another example is Larry Niven's science fiction writing of wire-heads in his "Known Space" stories.
Fear that the technology will be misused by the government and military is an early theme. In the 1981 BBC serial The Nightmare Man the pilot of a high-tech mini submarine is linked to his craft via a brain implant but becomes a savage killer after ripping out the implant.
Perhaps the most influential novel exploring the world of brain implants was William Gibson's 1984 novel Neuromancer. This was the first novel in a genre that came to be known as "cyberpunk". It follows a computer hacker through a world where mercenaries are augmented with brain implants to enhance strength, vision, memory, etc. Gibson coins the term "matrix" and introduces the concept of "jacking in" with head electrodes or direct implants. He also explores possible entertainment applications of brain implants such as the "simstim" (simulated stimulation) which is a device used to record and playback experiences.
Gibson's work led to an explosion in popular culture references to brain implants. Its influences are felt, for example, in the 1989 roleplaying game Shadowrun, which borrowed his term "datajack" to describe a brain-computer interface. The implants in Gibson's novels and short stories formed the template for the 1995 film Johnny Mnemonic and later, The Matrix Trilogy.
- The Gap Cycle (The Gap into): In Stephen R. Donaldson's series of novels, the use (and misuse) of "zone implant" technology is key to several plotlines.
- Ghost in the Shell anime and manga franchise: Cyberbrain neural augmentation technology is the focus. Implants of powerful computers provide vastly increased memory capacity, total recall, as well as the ability to view his or her own memories on an external viewing device. Users can also initiate a telepathic conversation with other cyberbrain users, the downsides being cyberbrain hacking, malicious memory alteration, and the deliberate distortion of subjective reality and experience.
- In Larry Niven and Jerry Pournelle's Oath of Fealty (1981) an arcology with high surveillance and feudal-like society is built by a private company due to riots around Los Angeles. Its systems are run by MILLIE, an advanced computer system, with some high-level executives being able to communicate directly with it and given omniscience of the arcology's workings via expensive implants in their brains.
- Brainstorm (1983): The military tries to take control over a new technology that can record and transfer thoughts, feelings, and sensations.
- RoboCop (1987) Science fiction action film. Police officer Alex Murphy is murdered and revived as a superhuman cyborg law enforcer.
- Johnny Mnemonic (1995): The main character acts as a "mnemonic courier" by way of a storage implant in his brain, allowing him to carry sensitive information undetected between parties.
- The Manchurian Candidate (2004): For a means of mind control, the presidential hopeful Raymond Shaw unknowingly has a chip implanted in his head by Manchurian Global, a fictional geopolitical organization aimed at making parts of the government sleeper cells, or puppets for their monetary advancement.
- Hardwired (2009): A corporation attempting to bring marketing to the next level implants a chip into main character's brain.
- Terminator Salvation (2009): A character named Marcus Wright discovers he is a Cyborg and must choose to fight for humans or an evil Artificial intelligence.
- The Happiness Cage (1972) A German scientist works on a way of quelling overly aggressive soldiers by developing implants that directly stimulate the pleasure centers of the brain. Also known as The Mind Snatchers.
- Six Million Dollar Man (1974 to 1978) Steve Austin suffers an accident and is rebuilt as a cyborg.
- The Bionic Woman (1976 to 1978) Jaime Sommers suffers an accident and is rebuilt as a cyborg.
- Blake's 7: Olag Gan, a character, has a brain implant which is supposed to prevent future aggression after being convicted of killing an officer from the oppressive Federation.
- Dark Angel: The notorious Red Series use neuro-implants pushed into their brain stem at the base of their skull to amp them up and hyper-adrenalize them and make them almost unstoppable. Unfortunately the effects of the implant burn out their system after six months to a year and kill them.
- The X-Files (episode:Duane Barry, relevant to the overreaching mytharc of the series.): FBI Agent Dana Scully discovers an implant set under the skin at the back of her neck which can read her every thought and change memory through electrical signals that alter the brain chemistry.
- Star Trek franchise: Members of the Borg collective are equipped with brain implants which connect them to the Borg collective consciousness.
- Stargate SG-1 franchise: Advanced replicators, the Asuran interface with humans by inserting their hand into the brain of humans.
- Fringe: The Observers use a needle like, self-guided implant which allows them to read the minds of others at the expense of emotion. The implant also allows for short range teleportation and increases intelligence.
- Person of Interest, Season 4. Episode 81 or 13. Title "M.I.A" "One of many innocent people who Samaritan operatives are experimenting on with neural implants."
- Brain implants appear in several episodes of The Outer Limits: in the episode "Straight and Narrow", students are forced to have brain implants and are controlled by them. In "The Message", a character named Jennifer Winter receives a brain implant to hear. In "Living Hell", a character named Ben Kohler receives a brain implant to save his life. And in "Judgment Day", a character who is judged a criminal has a chip implanted on the medulla oblongata of the lower brainstem . The forcibly implanted chip induces overwhelming pain and disorientation by a remote control within range. In the episode "Awakening", season three, episode 10, a neurologically impaired woman receives a brain implant to help her become more like a typical human.
- Black Mirror, a British science fiction television anthology series, has several episodes in which characters have implants on their head or in their brain or eyes, providing video recording and playback, augmented reality, and communication.
- Earth: Final Conflict, in season 1, episode 12, named "Sandoval's Run", the character named Sandoval experiences the breakdown of his brain implant.
- Earth: Final Conflict, in season 4, episode 12, named "The Summit", the character named Liam is implanted with a neural surveillance device.
- In the video games PlanetSide and Chrome, players can use implants to improve their aim, run faster, and see better, along with other enhancements.
- The Deus Ex video game series addresses the nature and impact of human enhancement with regard to a wide variety of prosthesis and brain implants. Deus Ex: Human Revolution, set in 2027, details the impact on society of human augmentation and the controversy it could generate. Several characters in the game have implanted neurochips to aid their professions (or their whims). Examples are of a helicopter pilot with implanted chips to better pilot her aircraft and analyse flight paths, velocity and spatial awareness, a CEO getting an artificial arm to throw a baseball better, as well as a hacker with a brain-computer interface that allows direct access to computer networks and also to act as a 'human proxy' to allow an individual in a remote location to control his actions.
- The game raises the question of the downsides of this kind of augmentation as those who cannot afford the enhancements (or object to getting them) rapidly find themselves at a serious disadvantage against people with artificial enhancement of their abilities. The spectre of being forced to have mechanical or electronic enhancements just to get a job is explored as well. The storyline addresses the effect of implant rejection by use of the fictional drug 'Neuropozyne' which breaks down glial tissue and is also fiercely addictive, leaving people who have augmentations little choice but to continue buying the drug from a single biotech corporation who controls the price of it. Without the drug augmented people experience rejection of implants (along with ensuing loss of implant functionality), crippling pain, and possible death.
- Krucoff, Max O.; Rahimpour, Shervin; Slutzky, Marc W.; Edgerton, V. Reggie; Turner, Dennis A. (2016-01-01). "Enhancing Nervous System Recovery through Neurobiologics, Neural Interface Training, and Neurorehabilitation". Frontiers in Neuroscience. 10: 584. doi:10.3389/fnins.2016.00584. ISSN 1662-4548. PMC 5186786. PMID 28082858.
- "Implantable Device that Blocks Brain Signals Shows Promise in Obesity". Medscape. Retrieved 2013-08-25.
- Patrick Mahoney (June 21, 2007). "Wireless is getting under our skin". Machine Design. Archived from the original on 2008-06-04. Retrieved 2011-08-14.
- Robitzski, Dan. "This Neural Implant Accesses Your Brain Through the Jugular Vein". Neoscope. Futurism. Retrieved 24 November 2019.
- Schmidt, E.M.; Bak, M.J.; McIntosh, J.S. (1976). "Long-term chronic recording from cortical neurons". Experimental Neurology. 52 (3): 496–506. doi:10.1016/0014-4886(76)90220-X. PMID 821770.
- "Cyberkinetics Microelectrode Arrays" (PDF). Archived from the original on March 24, 2006. Retrieved October 25, 2006.CS1 maint: BOT: original-url status unknown (link)
- Troyk, Philip; Bak, Martin; Berg, Joshua; Bradley, David; Cogan, Stuart; Erickson, Robert; Kufta, Conrad; McCreery, Douglas; Schmidt, Edward (2003). "A Model for Intracortical Visual Prosthesis Research". Artificial Organs. 27 (11): 1005–15. doi:10.1046/j.1525-1594.2003.07308.x. PMID 14616519.
- Blake, David T.; Heiser, Marc A.; Caywood, Matthew; Merzenich, Michael M. (2006). "Experience-Dependent Adult Cortical Plasticity Requires Cognitive Association between Sensation and Reward". Neuron. 52 (2): 371–81. doi:10.1016/j.neuron.2006.08.009. PMC 2826987. PMID 17046698.
- "Neuroscientists Demonstrate New Way to Control Prosthetic Device with Brain Signals" (Press release). Caltech. July 8, 2004. Archived from the original on July 19, 2011. Retrieved February 26, 2011.
- "Laboratory for Integrative Neural Systems | RIKEN". Riken.jp. Archived from the original on 2011-07-27. Retrieved 2011-08-14.
- "Blake Laboratory: Neural basis of behavior". Mcg.edu. 2007-08-16. Archived from the original on 2010-05-28. Retrieved 2011-08-14.
- "Robert H. Wurtz, Ph.D. [NEI Laboratories]". Nei.nih.gov. Archived from the original on 2011-07-27. Retrieved 2011-08-14.
- "Brain Research Institute". Faculty.bri.ucla.edu. Archived from the original on 2011-10-07. Retrieved 2011-08-14.
- "Making the connection between a sound and a reward changes brain and behavior". Physorg.com. 2006-10-19. Retrieved 2008-04-25.
- Chapin, John K. "Robot arm controlled using command signals recorded directly from brain neurons". SUNY Downstate Medical Center. Retrieved 2008-04-25.
- Graham-Rowe, Duncan (2003-10-13). "Monkey's brain signals control 'third arm'". New Scientist. Retrieved 2008-04-25.
- Mishra, Raja (2004-10-09). "Implant could free power of thought for paralyzed". Boston Globe. Retrieved 2008-04-25.
- Talmadoe, Eric (July 2001). "Japan's latest innovation: a remote-control roach". Associated Press. Retrieved 2008-04-25.
- Warwick, K.; Gasson, M; Hutt, B; Goodhew, I; Kyberd, P; Andrews, B; Teddy, P; Shad, A (2003). "The Application of Implant Technology for Cybernetic Systems". Archives of Neurology. 60 (10): 1369–73. doi:10.1001/archneur.60.10.1369. PMID 14568806.
- "Tiny electronic implants monitor brain injury, then melt away". University of Illinois at Urbana–Champaign. January 18, 2016.
- "Synchron Launches Trial of Stentrode device in Paralysis patients". Medical Device Network. April 9, 2019. Retrieved November 24, 2019.
- Military seeks to develop 'insect cyborgs'. Washington Times (13 March 2006). Retrieved on 29 August 2011.
- Military Plans Cyborg Sharks. LiveScience (7 March 2006). Retrieved on 29 August 2011.
- Lal A, Ewer J, Paul A, Bozkurt A, "Surgically Implanted Micro-platforms and Microsystems in Arthropods and Methods Based Thereon", US Patent Application # US20100025527, Filed on 12/11/2007.
- Paul A., Bozkurt A., Ewer J., Blossey B., Lal A. (2006) Surgically Implanted Micro-Platforms in Manduca-Sexta, 2006 Solid State Sensor and Actuator Workshop, Hilton Head Island, June 2006, pp 209–211.
- Bozkurt A, Gilmour R, Sinha A, Stern D, Lal A (2009). Insect Machine Interface Based Neuro Cybernetics. IEEE Transactions on Biomedical Engineering, 56:6, pp. 1727–33. doi:10.1109/TBME.2009.2015460
- Bozkurt A., Paul A., Pulla S., Ramkumar R., Blossey B., Ewer J., Gilmour R, Lal A. (2007) Microprobe Microsystem Platform Inserted During Early Metamorphosis to Actuate Insect Flight Muscle. 20th IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2007), Kobe, JAPAN, January 2007, pp. 405–408. doi:10.1109/MEMSYS.2007.4432976
- Bozkurt A, Gilmour R, Stern D, Lal A. (2008) MEMS based Bioelectronic Neuromuscular Interfaces for Insect Cyborg Flight Control. 21st IEEE International Conference on Micro Electro Mechanical Systems (MEMS 2008), Tucson, Arizona, January 2008, pp. 160–163. doi:10.1109/MEMSYS.2007.4432976
- Judy, Jack. "Hybrid Insect MEMS (HI-MEMS)". DARPA Microsystems Technology Office. Archived from the original on 10 February 2011. Retrieved 2013-04-09.
- Anthes, E. (17 February 2013). "The race to create 'insect cyborgs'". The Guardian. London. Retrieved 23 February 2013.
- Ornes, Stephen. "THE PENTAGON'S BEETLE BORGS." Discover 30.5 (2009): 14. Academic Search Complete. EBSCO. Web. 1 Mar. 2010.
- Weinberger, Sharon (2009-09-24). "Video: Pentagon's Cyborg Beetle Takes Flight". Wired. ISSN 1059-1028. Retrieved 2019-05-05.
- Bozkurt A, Lal A, Gilmour R. (2009) Radio Control of Insects for Biobotic Domestication. 4th International Conference of the IEEE Neural Engineering (NER'09), Antalya, Turkey.
- Guizzo, Eric. "Moth Pupa + MEMS Chip = Remote Controlled Cyborg Insect." Automan. IEEE Spectrum, 17 Feb 2009. Web. 1 Mar 2010..
- Judy, Jack. "Hybrid Insect MEMS (HI-MEMS)". DARPA Microsystems Technology Office. Archived from the original on 10 February 2011. Retrieved 2013-04-09.
The intimate control of insects with embedded microsystems will enable insect cyborgs, which could carry one or more sensors, such as a microphone or a gas sensor, to relay back information gathered from the target destination.
- "Minimally Invasive "Stentrode" Shows Potential as Neural Interface for Brain". DARPA. DARPA. February 8, 2016. Retrieved November 24, 2019.
- "Reliable Neural-Interface Technology (RE-NET)". DARPA. Retrieved November 24, 2019.
- "STENTRODE First in Human Early Feasibility Study (SWITCH)". ClinicalTrials.gov. April 4, 2019. Retrieved November 24, 2019.
- "Aufrüstung für den Krieg 4.0: Heer der Hacker im Dienst der Cyber-Abwehr" (in German). CHIP Online. Retrieved 9 April 2017.
- Arkhangelskaya, Svetlana (21 December 2015). "Cyborg rats will take on drug dealers and terrorists". Russia Beyond The Headlines. Retrieved 9 April 2017.
- Adams, Sam (4 January 2016). "Bomb-detecting RATS could replace sniffer dogs in battle against terrorists". Mirror. Retrieved 9 April 2017.
- Crilly, Rob (2016-07-05). "Engineers develop cyborg locusts to sniff out explosives". The Telegraph. Retrieved 9 April 2017.
- "Reliable Neural-Interface Technology (RE-NET)". DARPA.mil. DARPA. Retrieved 5 December 2019.
- Moan, Charles E.; Heath, Robert G. (1972). "Septal stimulation for the initiation of heterosexual behavior in a homosexual male". Journal of Behavior Therapy and Experimental Psychiatry. 3: 23–30. doi:10.1016/0005-7916(72)90029-8.
- Edwards, Christine A (September 2017). "Neurostimulation Devices for the Treatment of Neurologic Disorders". Mayo Clinic Proceedings. 92 (9): 1427–1444. doi:10.1016/j.mayocp.2017.05.005. PMID 28870357. Retrieved November 24, 2019.
- Burn, D. J.; Tröster, AI (2004). "Neuropsychiatric Complications of Medical and Surgical Therapies for Parkinson's Disease". Journal of Geriatric Psychiatry and Neurology. 17 (3): 172–80. doi:10.1177/0891988704267466. PMID 15312281.
- "SCIENCE AND TECHNOLOGY LAW: Neural Implants and Their Legal Implications | Solo, Small Firm and General Practice Division". www.americanbar.org. Retrieved 2017-02-27.
- Solon, Olivia (15 February 2017). "Elon Musk says humans must become cyborgs to stay relevant. Is he right?". The Guardian. Retrieved 9 April 2017.
- Putnam, Hilary (1981). Reason, Truth and History. Cambridge: Cambridge University Press. pp. 1–21. ISBN 9780511625398.
- Pringle, David (2014-06-30). Science Fiction: The 100 Best Novels. ISBN 978-0-947761-11-0. Retrieved 16 February 2016.
- Berger, Theodore W.; Glanzman, Dennis L., eds. (2005). Toward replacement parts for the brain: implantable biomimetic electronics as neural prostheses. Cambridge, Mass: MIT Press. ISBN 978-0-262-02577-5.
- Exclusive: A robot with a biological brain | Emerging Technology Trends | ZDNet.com
- Theodore Berger's Website
- Scientific American article on Jose Delgado
- Discover Magazine article on brain implants
- Neurotech Reports article on neural-silicon hybrid chips
- Parylene-c vs Acrylic Conformal Coatings used in Brain Implants
- BrainGate website
- 80,000 and Counting, Brain Implants on the Rise World Wide
- [permanent dead link] Brain Implant
- [permanent dead link] Encyclopedia of Computer Science
- [permanent dead link] IEE Explore