CD120 ( Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2). 
Receptor subtypes [ edit ]
There are two variants of the receptor, each encoded by a separate gene:
CD120a - TNFR1 - TNFR superfamily member 1A
CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,
and is involved in neurotoxic processes.  Elevated levels of TNFR1 has been found in severe mental disorders. 
Signaling pathway [ edit ]
Signaling pathway of
-R1. Dashed grey lines represent multiple steps
See also [ edit ]
References [ edit ]
Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell. 104 (4): 487–501. doi: 10.1016/S0092-8674(01)00237-9. PMID 11239407. S2CID 7657797.
Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology. 115 (1): 1–20. doi: 10.1111/j.1365-2567.2005.02143.x. PMC . 1782125 PMID 15819693.
Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology. 201 (4): 549–56. doi: 10.1007/s00213-008-1331-4. PMC . 2711641 PMID 18825372.
McCoy MK, Tansey MG (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation. 5 (1): 45. doi: 10.1186/1742-2094-5-45. PMC . 2577641 PMID 18925972.
Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord. 11 (7): 726–34. doi: 10.1111/j.1399-5618.2009.00757.x. hdl: . 10852/34620 PMID 19839997.
External links [ edit ]