CD226

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CD226
Identifiers
AliasesCD226, DNAM-1, DNAM1, PTA1, TLiSA1, CD226 molecule
External IDsOMIM: 605397 MGI: 3039602 HomoloGene: 4787 GeneCards: CD226
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for CD226
Genomic location for CD226
Band18q22.2Start69,831,158 bp[1]
End69,961,803 bp[1]
RNA expression pattern
PBB GE CD226 207315 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001303618
NM_001303619
NM_006566

NM_001039148
NM_001039149
NM_178687

RefSeq (protein)

NP_001290547
NP_001290548
NP_006557

NP_001034238
NP_848802

Location (UCSC)Chr 18: 69.83 – 69.96 MbChr 18: 89.18 – 89.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')[5] or DNAM-1 (DNAX Accessory Molecule-1)[5] is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.[6]


Structure and function[edit]

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set.[7]

CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,[7][8] and cross-linking CD226 with antibodies causes cellular activation.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000150637 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034028 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–66. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
  6. ^ a b "Entrez Gene: CD226 CD226 molecule".
  7. ^ a b Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". The Journal of Experimental Medicine. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.
  8. ^ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". International Immunology. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.