CD53

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CD53
Identifiers
AliasesCD53, MOX44, TSPAN25, CD53 molecule
External IDsOMIM: 151525 MGI: 88341 HomoloGene: 20152 GeneCards: CD53
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CD53
Genomic location for CD53
Band1p13.3Start110,871,188 bp[1]
End110,899,922 bp[1]
RNA expression pattern
PBB GE CD53 203416 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000560
NM_001040033
NM_001320638

NM_007651

RefSeq (protein)

NP_000551
NP_001035122
NP_001307567

NP_031677

Location (UCSC)Chr 1: 110.87 – 110.9 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.[4][5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143119 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Korinek V, Horejsi V (Jul 1993). "Genomic structure of the human CD53 gene". Immunogenetics. 38 (4): 272–279. doi:10.1007/BF00188803. PMID 8319976.
  5. ^ a b "Entrez Gene: CD53 CD53 molecule".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.