Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein.
Angelisová P, Vlcek C, Stefanová I, et al. (1990). "The human leucocyte surface antigen CD53 is a protein structurally similar to the CD37 and MRC OX-44 antigens". Immunogenetics. 32 (4): 281–285. doi:10.1007/BF00187099. PMID1700763.
Amiot M (1991). "Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte antigen related to membrane transport proteins". J. Immunol. 145 (12): 4322–5. PMID2258620.
Dianzani U, Bragardo M, Buonfiglio D, et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". Eur. J. Immunol. 25 (5): 1306–1311. doi:10.1002/eji.1830250526. PMID7539755.
Carmo AM, Wright MD (1995). "Association of the transmembrane 4 superfamily molecule CD53 with a tyrosine phosphatase activity". Eur. J. Immunol. 25 (7): 2090–2095. doi:10.1002/eji.1830250743. PMID7621882.
Rasmussen AM, Blomhoff HK, Stokke T, et al. (1994). "Cross-linking of CD53 promotes activation of resting human B lymphocytes". J. Immunol. 153 (11): 4997–5007. PMID7963560.
Olweus J, Lund-Johansen F, Horejsi V (1993). "CD53, a protein with four membrane-spanning domains, mediates signal transduction in human monocytes and B cells". J. Immunol. 151 (2): 707–16. PMID8335905.
Taguchi T, Bellacosa A, Zhou JY, et al. (1993). "Chromosomal localization of the Ox-44 (CD53) leukocyte antigen gene in man and rodents". Cytogenet. Cell Genet. 64 (3–4): 217–221. doi:10.1159/000133580. PMID8404042.
Virtaneva KI, Angelisová P, Baumruker T, et al. (1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6): 461–465. doi:10.1007/BF00222471. hdl:10138/157839. PMID8436422.
Wright MD, Rochelle JM, Tomlinson MG, et al. (1993). "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". Int. Immunol. 5 (2): 209–216. doi:10.1093/intimm/5.2.209. PMID8452817.
Mannion BA, Berditchevski F, Kraeft SK, et al. (1996). "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". J. Immunol. 157 (5): 2039–47. PMID8757325.
Szöllósi J, Horejsí V, Bene L, et al. (1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". J. Immunol. 157 (7): 2939–46. PMID8816400.
Okochi H, Kato M, Nashiro K, et al. (1998). "Expression of tetra-spans transmembrane family (CD9, CD37, CD53, CD63, CD81 and CD82) in normal and neoplastic human keratinocytes: an association of CD9 with alpha 3 beta 1 integrin". Br. J. Dermatol. 137 (6): 856–863. doi:10.1111/j.1365-2133.1997.tb01544.x. PMID9470900.