CD96

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CD96
Identifiers
AliasesCD96, TACTILE, CD96 molecule
External IDsOMIM: 606037 MGI: 1934368 HomoloGene: 68489 GeneCards: CD96
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CD96
Genomic location for CD96
Band3q13.13-q13.2Start111,292,719 bp[1]
End111,665,750 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005816
NM_198196
NM_001318889

NM_032465

RefSeq (protein)

NP_001305818
NP_005807
NP_937839
NP_001305818.1

NP_115854

Location (UCSC)Chr 3: 111.29 – 111.67 MbChr 16: 46.04 – 46.12 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a protein that in humans is encoded by the CD96 gene.[5] CD96 is a receptor protein which is expressed on T cells and NK cells and shares sequence similarity with CD226 (also known as DNAM-1).[6] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation[citation needed]. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.[7]

Function[edit]

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016].

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153283 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022657 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CD96 molecule". Retrieved 2018-07-03.
  6. ^ Fuchs, Anja; Colonna, M. (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Semin. Cancer Biol. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
  7. ^ Smyth, Mark J.; Martinet, L. (March 2015). "Balancing natural killer cell activation through paired receptors". Nature Reviews Immunology. 15 (4): 243–254. doi:10.1038/nri3799. PMID 25743219.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.