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Available structures
PDBOrtholog search: PDBe RCSB
AliasesCDK13, CDC2L, CDC2L5, CHED, hcyclin-dependent kinase 13, cyclin dependent kinase 13, CHDFIDD
External IDsOMIM: 603309 MGI: 1916812 HomoloGene: 135707 GeneCards: CDK13
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CDK13
Genomic location for CDK13
Band7p14.1Start39,950,121 bp[1]
End40,099,580 bp[1]
RNA expression pattern
PBB GE CDC2L5 210965 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 7: 39.95 – 40.1 MbChr 13: 17.71 – 17.81 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Cell division cycle 2-like protein kinase 5 is an enzyme that in humans is encoded by the CDC2L5 gene.[5][6]

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to phosphorylate proteins that are important for cell differentiation and apoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.[6]

A 2017 study of children with rare developmental disorders[7] found 11 children in the United Kingdom who had a fault in their CDK13 gene. This fault affected the children's communication and language skills as well as causing learning difficulties.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000065883 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041297 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lapidot-Lifson Y, Patinkin D, Prody CA, Ehrlich G, Seidman S, Ben-Aziz R, Benseler F, Eckstein F, Zakut H, Soreq H (Feb 1992). "Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis". Proc Natl Acad Sci U S A. 89 (2): 579–83. doi:10.1073/pnas.89.2.579. PMC 48282. PMID 1731328.
  6. ^ a b "Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)".
  7. ^ McRae, Jeremy F.; Clayton, Stephen; Fitzgerald, Tomas W.; Kaplanis, Joanna; Prigmore, Elena; Rajan, Diana; Sifrim, Alejandro; Aitken, Stuart; Akawi, Nadia (2017). "Prevalence and architecture of de novo mutations in developmental disorders". Nature. 542 (7642): 433–438. doi:10.1038/nature21062. hdl:20.500.11820/a89badba-7288-4be1-b3c5-a9b9e61d920d.
  8. ^ Walsh, Fergus (2017-01-25). "Child gene study identifies new developmental disorders". BBC News. Retrieved 2017-01-27.

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