CDH11

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CDH11
Protein CDH11 PDB 2a4c.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDH11, CAD11, CDHOB, OB, OSF-4, cadherin 11, ESWS
External IDsMGI: 99217 HomoloGene: 1361 GeneCards: CDH11
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for CDH11
Genomic location for CDH11
Band16q21Start64,943,753 bp[1]
End65,126,112 bp[1]
RNA expression pattern
PBB GE CDH11 207172 s at fs.png

PBB GE CDH11 207173 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308392
NM_001797
NM_001330576

NM_009866

RefSeq (protein)

NP_001295321
NP_001317505
NP_001788

NP_033996

Location (UCSC)Chr 16: 64.94 – 65.13 MbChr 8: 102.63 – 102.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-11 is a protein that in humans is encoded by the CDH11 gene.[5][6]

Function[edit]

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.[6] The mammalian CDH-11 homologues are termed calsyntenin.[7]

Relevance to cancer[edit]

CDH11 is overexpressed in 15% of breast cancers and seems essential to tumour progression in some other cancer types.[8][9]

Drug interactions[edit]

Arthritis drug celecoxib binds to CDH11.[8][9]

Interactions[edit]

CDH11 has been shown to interact with CDH2.[10]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000140937 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031673 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
  6. ^ a b "Entrez Gene: CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)".
  7. ^ Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P (2001). "Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain". Mol. Cell. Neurosci. 17 (1): 151–66. doi:10.1006/mcne.2000.0937. PMID 11161476.
  8. ^ a b "New Therapeutic Approach Could Target Both Cancer and Arthritis". 15 Nov 2013.
  9. ^ a b Assefnia S, Dakshanamurthy S, Guidry Auvil JM, Hampel C, Anastasiadis PZ, Kallakury B, Uren A, Foley DW, Brown ML, Shapiro L, Brenner M, Haigh D, Byers SW (Mar 2014). "Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies". Oncotarget. 5 (6): 1458–74. doi:10.18632/oncotarget.1538. PMC 4039224. PMID 24681547.
  10. ^ Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (Dec 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.

Further reading[edit]

External links[edit]