CENPO

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CENPO
Identifiers
AliasesCENPO, CENP-O, ICEN-36, MCM21R, centromere protein O
External IDsOMIM: 611504 MGI: 1923800 HomoloGene: 49760 GeneCards: CENPO
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CENPO
Genomic location for CENPO
Band2p23.3Start24,793,136 bp[1]
End24,822,376 bp[1]
RNA expression pattern
PBB GE CENPO 219472 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199803
NM_024322
NM_001322101

NM_134046
NM_001361641

RefSeq (protein)

NP_001186732
NP_001309030
NP_077298

NP_598807
NP_001348570

Location (UCSC)Chr 2: 24.79 – 24.82 MbChr 12: 4.2 – 4.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene.[5][6][7] CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. [8]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138092 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020652 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
  6. ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
  7. ^ "Entrez Gene: CENPO centromere protein O".
  8. ^ Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, Matthew E.; King, Sarah L.; Pritchard, Melanie A.; Smyth, Gordon K.; Thomas, Tim (2010-07-16). "Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome". PLOS ONE. 5 (7): e11561. doi:10.1371/journal.pone.0011561. ISSN 1932-6203. PMC 2905390. PMID 20661276.

External links[edit]

Further reading[edit]