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AliasesCLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1
External IDsOMIM: 603906 MGI: 1346342 HomoloGene: 984 GeneCards: CLCA1
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CLCA1
Genomic location for CLCA1
Band1p22.3Start86,468,368 bp[1]
End86,500,289 bp[1]
RNA expression pattern
PBB GE CLCA1 210107 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 86.47 – 86.5 MbChr 3: 145 – 145.03 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.[5][6]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000016490 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028255 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl channel proteins". Genomics. 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122.
  6. ^ a b "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".
  7. ^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.