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AliasesCXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDsOMIM: 605163 MGI: 1934582 HomoloGene: 38197 GeneCards: CXCR6
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 45.94 – 45.95 MbChr 9: 123.81 – 123.81 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.[5][6][7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.[5][6][7][8] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000172215 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048521 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (June 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". The Journal of Experimental Medicine. 185 (11): 2015–23. doi:10.1084/jem.185.11.2015. PMC 2196334. PMID 9166430.
  6. ^ a b Deng HK, Unutmaz D, KewalRamani VN, Littman DR (July 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature. 388 (6639): 296–300. Bibcode:1997Natur.388..296D. doi:10.1038/40894. PMID 9230441. S2CID 4369660.
  7. ^ a b "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6".
  8. ^ a b Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG (September 2015). "Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV". Journal of Virology. 89 (18): 9252–61. doi:10.1128/JVI.01236-15. PMC 4542357. PMID 26109719.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.