Chlormadinone caproate

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Chlormadinone caproate
Chlormadinone caproate.svg
Clinical data
Other namesCMC; Chlormadinone hexanoate; 6-Chloro-17α-hydroxy-Δ6-progesterone hexanoate; 6-Chloro-17α-hydroxypregna-4,6-diene-3,20-dione hexanoate
Routes of
Intramuscular injection
Drug classProgestogen; Progestin; Progestogen ester
CAS Number
Chemical and physical data
Molar mass461.040 g/mol g·mol−1
3D model (JSmol)

Chlormadinone caproate (CMC) is a progestin and a progestogen ester which was studied for potential use in combined injectable contraceptives but was never marketed.[1][2][3][4] It was assessed in combination with estradiol valerate at doses of 80 mg and 3 mg, respectively.[1][2][3] In addition to chlormadinone acetate (CMA), analogues of CMC include gestonorone caproate, hydroxyprogesterone caproate, medroxyprogesterone caproate, megestrol caproate, and methenmadinone caproate.

See also[edit]


  1. ^ a b Daniel R. Mishell (1983). Long-acting Steroid Contraception. Raven Press. pp. 69, 77. ISBN 978-0-89004-932-7.
  2. ^ a b Toppozada MK (April 1994). "Existing once-a-month combined injectable contraceptives". Contraception. 49 (4): 293–301. doi:10.1016/0010-7824(94)90029-9. PMID 8013216.
  3. ^ a b Newton JR, D'arcangues C, Hall PE (1994). "A review of "once-a-month" combined injectable contraceptives". J Obstet Gynaecol (Lahore). 4 Suppl 1: S1–34. doi:10.3109/01443619409027641. PMID 12290848.
  4. ^ Bopp RJ, Murphy HW, Nash JF, Novotny CR (September 1972). "GLC determination of chlormadinone acetate in plasma". J Pharm Sci. 61 (9): 1441–4. doi:10.1002/jps.2600610919. PMID 4115914.