Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.
EIF4E3 belongs to the
EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome. 
Model organisms [ edit ] Model organisms have been used in the study of EIF4E3 function. A conditional knockout mouse line, called Eif4e3 tm1a(KOMP)Wtsi  was generated as part of the  International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.  
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion.  Twenty four tests were carried out on  mutant mice but no significant abnormalities were observed.
References [ edit ]
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GRCh38: Ensembl release 89: ENSG00000163412 - Ensembl, May 2017
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GRCm38: Ensembl release 89: ENSMUSG00000093661 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ a b
"Entrez Gene: Eukaryotic translation initiation factor 4E family member 3" . Retrieved . 2011-09-28
Joshi, B.; Cameron, A.; Jagus, R. (2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi: 10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
". Wellcome Trust Sanger Institute. Salmonella infection data for Eif4e3"
". Wellcome Trust Sanger Institute. Citrobacter infection data for Eif4e3"
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Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248): 0. doi: 10.1111/j.1755-3768.2010.4142.x.
Mouse Resources Portal, Wellcome Trust Sanger Institute.
"International Knockout Mouse Consortium".
"Mouse Genome Informatics".
Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi: 10.1038/nature10163. PMC . 3572410 PMID 21677750.
Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a. PMID 21677718.
Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018. PMID 17218247.
van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi: 10.1186/gb-2011-12-6-224. PMC . 3218837 PMID 21722353.
External links [ edit ]
Overview of all the structural information available in the PDB for UniProt: (Mouse Eukaryotic translation initiation factor 4E type 3) at the Q9DBB5 PDBe-KB.