EML4

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EML4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4, EMAP like 4
External IDsOMIM: 607442 MGI: 1926048 HomoloGene: 56841 GeneCards: EML4
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for EML4
Genomic location for EML4
Band2p21Start42,169,353 bp[1]
End42,332,548 bp[1]
RNA expression pattern
PBB GE EML4 220386 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145076
NM_019063

NM_001114361
NM_001114362
NM_001286567
NM_199466
NM_001357886

RefSeq (protein)

NP_001138548
NP_061936

NP_001107833
NP_001107834
NP_001273496
NP_955760
NP_001344815

Location (UCSC)Chr 2: 42.17 – 42.33 MbChr 17: 83.35 – 83.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.[5]

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143924 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032624 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
  6. ^ Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Echinoderm microtubule-associated protein-like 4 (EML4)