Fibrinogen alpha chain

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FGA
Protein FGA PDB 1fza.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFGA, Fib2, fibrinogen alpha chain
External IDsOMIM: 134820 MGI: 1316726 HomoloGene: 428 GeneCards: FGA
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for FGA
Genomic location for FGA
Band4q31.3Start154,583,128 bp[1]
End154,590,745 bp[1]
RNA expression pattern
PBB GE FGA 205650 s at fs.png

PBB GE FGA 205649 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000508
NM_021871

NM_001111048
NM_010196

RefSeq (protein)

NP_000499
NP_068657

NP_001104518
NP_034326

Location (UCSC)Chr 4: 154.58 – 154.59 MbChr 3: 83.03 – 83.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene.

Function[edit]

The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia, and renal amyloidosis. Alternative splicing results in two isoforms that vary in the carboxy-terminus.[5]

Interactions[edit]

Fibrinogen alpha chain has been shown to interact with tissue plasminogen activator.[6][7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171560 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028001 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: FGA fibrinogen alpha chain".
  6. ^ Tsurupa G, Medved L (Jan 2001). "Identification and characterization of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains". Biochemistry. 40 (3): 801–808. doi:10.1021/bi001789t. PMID 11170397.
  7. ^ Ichinose A, Takio K, Fujikawa K (Jul 1986). "Localization of the binding site of tissue-type plasminogen activator to fibrin". The Journal of Clinical Investigation. 78 (1): 163–169. doi:10.1172/JCI112546. PMC 329545. PMID 3088041.

Further reading[edit]