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Available structures
PDBOrtholog search: PDBe RCSB
AliasesGUCY1B1, GC-S-beta-1, GC-SB3, GUC1B3, GUCB3, GUCSB3, guanylate cyclase 1, soluble, beta 3, guanylate cyclase 1 soluble subunit beta, GUCY1B3, guanylate cyclase 1 soluble subunit beta 1
External IDsOMIM: 139397 MGI: 1860604 HomoloGene: 664 GeneCards: GUCY1B1
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for GUCY1B1
Genomic location for GUCY1B1
Band4q32.1Start155,758,992 bp[1]
End155,807,774 bp[1]
RNA expression pattern
PBB GE GUCY1B3 211555 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 4: 155.76 – 155.81 MbChr 3: 82.03 – 82.07 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.[5][6]


Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.[6]


GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[7] and Endothelial NOS.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000061918 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028005 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
  6. ^ a b "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".
  7. ^ a b Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.

Further reading[edit]