Gallamine triethiodide

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Gallamine triethiodide
Gallamine triethiodide.svg
Clinical data
Trade namesFlaxedil
AHFS/Drugs.comInternational Drug Names
ATC code
CAS Number
PubChem CID
Chemical and physical data
FormulaC30H60N3O3+3 · 3 I (gallamine triethiodide)
C24H45N3O3 (gallamine)
Molar mass891.529 g/mol (gallamine triethiodide)
423.633 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.[2] Gallamine is a non-depolarising type of blocker as it binds to the acetylcholine receptor but does not have the biological activity of acetyl choline.Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve, which causes tachycardia[3][4] and occasionally hypertension. Very high doses cause histamine release.[citation needed]

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.[5]

The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.

An ampoule of gallamine.


  1. ^ "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.[permanent dead link]
  2. ^ "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.
  3. ^ Morgenstern C, Splith G (October 1965). "[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics]". Der Anaesthesist (in German). 14 (10): 298–301. PMID 4380161.
  4. ^ Walts LF (1963). "Ventricular tachycardia with gallamine and cyclopropane anesthesia". Anesthesiology. 24: 119. doi:10.1097/00000542-196301000-00024. PMID 13998750.
  5. ^ Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". Journal of the Royal Society of Medicine. 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.