Gem-associated protein 2

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesGEMIN2, SIP1, SIP1-delta, Survival of motor neuron protein-interacting protein 1, gem nuclear organelle associated protein 2
External IDsOMIM: 602595 MGI: 1913853 HomoloGene: 37827 GeneCards: GEMIN2
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for GEMIN2
Genomic location for GEMIN2
Band14q21.1Start39,114,223 bp[1]
End39,136,973 bp[1]
RNA expression pattern
PBB GE SIP1 210779 x at fs.png

PBB GE SIP1 205063 at fs.png

PBB GE SIP1 211114 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 14: 39.11 – 39.14 MbChr 12: 59.01 – 59.03 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.[5][6][7]


Gem-associated protein 2 has been shown to interact with DDX20[8][9] and SMN1.[6][10][11]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000092208 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060121 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fischer U, Liu Q, Dreyfuss G (October 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis". Cell. 90 (6): 1023–9. doi:10.1016/S0092-8674(00)80368-2. PMID 9323130.
  6. ^ a b Liu Q, Fischer U, Wang F, Dreyfuss G (October 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
  7. ^ "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1".
  8. ^ Mourelatos, Zissimos; Dostie Josée; Paushkin Sergey; Sharma Anup; Charroux Bernard; Abel Linda; Rappsilber Juri; Mann Matthias; Dreyfuss Gideon (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. ISSN 0890-9369. PMC 155365. PMID 11914277.
  9. ^ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333.
  10. ^ Carnegie, Graeme K; Sleeman Judith E; Morrice Nick; Hastie C James; Peggie Mark W; Philp Amanda; Lamond Angus I; Cohen Patricia T W (May 2003). "Protein phosphatase 4 interacts with the Survival of motor neurons complex and enhances the temporal localisation of snRNPs". J. Cell Sci. 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. ISSN 0021-9533. PMID 12668731.
  11. ^ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426.

Further reading[edit]