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Great Work or great work may refer to:
- A masterpiece or magnum opus, a creation that has been given much critical praise
- Magnum opus (alchemy), the process of working with the prima materia to create the philosopher's stone
- Great Work (Hermeticism), also known as magnum opus, a term used in Hermeticism and in certain occult traditions and religions such as Thelema
- Great Work (Thelema), spiritual practices leading to the mystical union of the Self and the All
| disambiguation page lists articles associated with the title Great Work.
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