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Protein HCN2 PDB 1q3e.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesHCN2, BCNG-2, BCNG2, HAC-1, hyperpolarization activated cyclic nucleotide gated potassium channel 2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
External IDsOMIM: 602781 MGI: 1298210 HomoloGene: 31022 GeneCards: HCN2
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for HCN2
Genomic location for HCN2
Band19p13.3Start589,881 bp[1]
End617,159 bp[1]
RNA expression pattern
PBB GE HCN2 207592 s at fs.png

PBB GE HCN2 214893 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 0.59 – 0.62 MbChr 10: 79.72 – 79.74 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.[5][6][7][8]


HCN2 has been shown to interact with HCN1[9][10] and HCN4.[9]


The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.[11]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099822 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020331 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Santoro B, Grant SG, Bartsch D, Kandel ER (Dec 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
  6. ^ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell. 93 (5): 717–29. doi:10.1016/S0092-8674(00)81434-8. PMID 9630217.
  7. ^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
  8. ^ "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2".
  9. ^ a b Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S, Ludwig A, Biel M (Oct 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
  10. ^ Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry. 277 (33): 29634–42. doi:10.1074/jbc.M200504200. PMID 12034718.
  11. ^ "Gene find may lead to pills that kill chronic pain". The Times Of India. 10 September 2011.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.