IL18R1

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IL18R1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL18R1, CD218a, CDw218a, IL-1Rrp, IL18RA, IL1RRP, interleukin 18 receptor 1, IL-18R-alpha, IL18Ralpha2, IL-18Ralpha
External IDsOMIM: 604494 MGI: 105383 HomoloGene: 2861 GeneCards: IL18R1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for IL18R1
Genomic location for IL18R1
Band2q12.1Start102,311,529 bp[1]
End102,398,775 bp[1]
RNA expression pattern
PBB GE IL18R1 206618 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161842
NM_001161843
NM_008365

RefSeq (protein)

NP_001155314
NP_001155315
NP_032391

Location (UCSC)Chr 2: 102.31 – 102.4 MbChr 1: 40.47 – 40.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.[5] IL18R1 is also known as CDw218a (cluster of differentiation w218a).

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.[5]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115604 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026070 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL18R1 interleukin 18 receptor 1".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.