Integrin alpha 2b

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Protein ITGA2B PDB 1txv.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b
External IDsOMIM: 607759 MGI: 96601 HomoloGene: 37304 GeneCards: ITGA2B
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ITGA2B
Genomic location for ITGA2B
Band17q21.31Start44,372,180 bp[1]
End44,389,649 bp[1]
RNA expression pattern
PBB GE ITGA2B 216956 s at fs.png

PBB GE ITGA2B 206493 at fs.png

PBB GE ITGA2B 206494 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 44.37 – 44.39 MbChr 11: 102.45 – 102.47 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[5]


ITGA2B has been shown to interact with AUP1[6] and CLNS1A.[7]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000005961 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034664 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".
  6. ^ Kato, Atsushi; Kawamata Norihiko; Tamayose Kenji; Egashira Motoki; Miura Rika; Fujimura Tsutomu; Murayama Kimie; Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. United States. 277 (32): 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322.
  7. ^ Larkin, Deirdre; Murphy Derek; Reilly Dermot F; Cahill Martha; Sattler Ellen; Harriott Pat; Cahill Dolores J; Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. United States. 279 (26): 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.

Further reading[edit]

External links[edit]