Keratin 4

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AliasesKRT4, CK-4, CK4, CYK4, K4, WSN1, Keratin 4
External IDsOMIM: 123940 MGI: 96701 HomoloGene: 20523 GeneCards: KRT4
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for KRT4
Genomic location for KRT4
Band12q13.13Start52,806,549 bp[1]
End52,814,116 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 12: 52.81 – 52.81 MbChr 15: 101.92 – 101.92 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.[5][6]

Keratin 4 is a type II cytokeratin. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13. Mutations in the genes encoding this protein have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170477 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059668 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V (1990). "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenet. Cell Genet. 54 (3–4): 148–50. doi:10.1159/000132979. PMID 1702379.
  6. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  7. ^ Chao SC, Tsai YM, Yang MH, Lee JY (June 2003). "A novel mutation in the keratin 4 gene causing white sponge naevus". Br. J. Dermatol. 148 (6): 1125–8. doi:10.1046/j.1365-2133.2003.05337.x. PMID 12828738. S2CID 26905614.

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