LAIR1

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LAIR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLAIR1, CD305, LAIR-1, leukocyte associated immunoglobulin like receptor 1
External IDsOMIM: 602992 MGI: 105492 HomoloGene: 48097 GeneCards: LAIR1
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LAIR1
Genomic location for LAIR1
Band19q13.42Start54,351,384 bp[1]
End54,370,558 bp[1]
RNA expression pattern
PBB GE LAIR1 208071 s at fs.png

PBB GE LAIR1 210644 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 19: 54.35 – 54.37 MbChr 7: 4 – 4.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[5][6] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

Function[edit]

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells.[7] Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[6]

Interactions[edit]

LAIR1 has been shown to interact with PTPN11[5][8] and PTPN6.[5][8][9][10][11]

References[edit]

  1. ^ a b c ENSG00000276163, ENSG00000278154, ENSG00000274110, ENSG00000167613 GRCh38: Ensembl release 89: ENSG00000276053, ENSG00000276163, ENSG00000278154, ENSG00000274110, ENSG00000167613 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000055541 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity. 7 (2): 283–90. doi:10.1016/S1074-7613(00)80530-0. PMID 9285412.
  6. ^ a b "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1".
  7. ^ van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (October 1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". European Journal of Immunology. 29 (10): 3160–7. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. PMID 10540327.
  8. ^ a b Fournier N, Chalus L, Durand I, Garcia E, Pin JJ, Churakova T, Patel S, Zlot C, Gorman D, Zurawski S, Abrams J, Bates EE, Garrone P (August 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. doi:10.4049/jimmunol.165.3.1197. PMID 10903717.
  9. ^ Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ, Matthews RJ (February 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. doi:10.4049/jimmunol.166.3.1763. PMID 11160222.
  10. ^ Mousseau DD, Banville D, L'Abbé D, Bouchard P, Shen SH (February 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.
  11. ^ Xu Mj, Zhao R, Zhao ZJ (June 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. doi:10.1074/jbc.M001313200. PMID 10764762.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.