LILRB5

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LILRB5
Identifiers
AliasesLILRB5, CD85C, LIR-8, LIR8, leukocyte immunoglobulin like receptor B5
External IDsHomoloGene: 134027 GeneCards: LILRB5
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for LILRB5
Genomic location for LILRB5
Band19q13.42Start54,249,431 bp[1]
End54,257,301 bp[1]
RNA expression pattern
PBB GE LILRB5 206856 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081442
NM_001081443
NM_001304457
NM_006840

n/a

RefSeq (protein)

NP_001074911
NP_001074912
NP_001291386
NP_006831

n/a

Location (UCSC)Chr 19: 54.25 – 54.26 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.[3][4]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.[4]

References[edit]

  1. ^ a b c ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 GRCh38: Ensembl release 89: ENSG00000274311, ENSG00000278437, ENSG00000273991, ENSG00000277414, ENSG00000105609 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol. 159 (11): 5192–6. PMID 9548455.
  4. ^ a b "Entrez Gene: LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5".

Further reading[edit]