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AliasesLPAR3, EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDsOMIM: 605106 MGI: 1929469 HomoloGene: 8123 GeneCards: LPAR3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for LPAR3
Genomic location for LPAR3
Band1p22.3Start84,811,602 bp[1]
End84,893,206 bp[1]
RNA expression pattern
PBB GE EDG7 220816 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 1: 84.81 – 84.89 MbChr 3: 146.22 – 146.29 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene.[5][6] LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[7]


This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.[5]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171517 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036832 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3".
  6. ^ Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K (September 1999). "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. doi:10.1074/jbc.274.39.27776. PMID 10488122.
  7. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.