LTBP1 (gene)

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LTBP1
Protein LTBP1 PDB 1ksq.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLTBP1, latent transforming growth factor beta binding protein 1
External IDsMGI: 109151 HomoloGene: 522 GeneCards: LTBP1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for LTBP1
Genomic location for LTBP1
Band2p22.3Start32,946,953 bp[1]
End33,399,509 bp[1]
RNA expression pattern
PBB GE LTBP1 202728 s at fs.png

PBB GE LTBP1 202729 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000627
NM_001166264
NM_001166265
NM_001166266
NM_206943

RefSeq (protein)

NP_000618
NP_001159736
NP_001159737
NP_001159738
NP_996826

Location (UCSC)Chr 2: 32.95 – 33.4 MbChr 17: 75.01 – 75.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Latent-transforming growth factor beta-binding protein 1 is a protein that in humans is encoded by the LTBP1 gene.[5][6][7]

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

Interactions[edit]

LTBP1 (gene) has been shown to interact with TGF beta 1.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000049323 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001870 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Kanzaki T, Olofsson A, Moren A, Wernstedt C, Hellman U, Miyazono K, Claesson-Welsh L, Heldin CH (July 1990). "TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences". Cell. 61 (6): 1051–1061. doi:10.1016/0092-8674(90)90069-Q. PMID 2350783.
  6. ^ Oklu R, Hesketh R (January 2001). "The latent transforming growth factor beta binding protein (LTBP) family". Biochem J. 352 (3): 601–10. doi:10.1042/0264-6021:3520601. PMC 1221494. PMID 11104663.
  7. ^ a b "Entrez Gene: LTBP1 latent transforming growth factor beta binding protein 1".
  8. ^ Saharinen, J; Keski-Oja J (August 2000). "Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta". Mol. Biol. Cell. 11 (8): 2691–704. doi:10.1091/mbc.11.8.2691. ISSN 1059-1524. PMC 14949. PMID 10930463.

Further reading[edit]