Clow is best known for co-creating – along with Steve Hayden – Apple Computer's 1984 commercial, which launched the Apple Macintosh and the "Think Different" slogan. The 60-second TV spot was made for a budget of $900,000 and is considered a masterpiece in advertising.
He is also known for his work on the PlayStation, Energizer Bunny, Taco Bell chihuahua, and California Cooler campaigns. Clow has helmed campaigns for Nissan and Pedigree Petfoods. He is a member of numerous advertising and creative halls of fame.
Per his likes on Twitter, Clow is also a heavy COVID denier, with him routinely liking tweets by Newsmax and The Daily Caller. 
- "Duncan Milner Ascends at TBWA/Media Arts Lab". Retrieved 2018-10-02.
- "Lee Clow". Retrieved 2018-10-02.
- "Archived copy". Archived from the original on 2007-03-17. Retrieved 2007-05-04. CS1 maint: discouraged parameter (link) CS1 maint: archived copy as title (link)
- "Sony TV: Turn On, Tune In, Buy Hardware". Next Generation. No. 14. Imagine Media. February 1996. pp. 72–73.
- Friday, AppleInsider Staff; October 30; 2009; PT, 10:50 am. "Visionary behind Apple's '1984' advertisement steps down". AppleInsider.CS1 maint: numeric names: authors list (link)
- Friday, Lee Clow Staff; October 30; 2009; PT, 10:50 am. "Lee Flow's liked tweets". Twitter.CS1 maint: numeric names: authors list (link)
- Art Directors Club - biography, portrait and images of work (1990)
- Ihaveanidea - interview with Lee Clow (2004)
- Lee Clow's Beard - information on a Twitter-feed-turned-book featuring Lee Clow (2012)