From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
PBB Protein MRPL11 image.jpg
AliasesMRPL12, 5c5-2, L12mt, MRP-L31/34, MRPL7, MRPL7/L12, RPML12, mitochondrial ribosomal protein L12
External IDsOMIM: 602375 MGI: 1926273 HomoloGene: 2212 GeneCards: MRPL12
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MRPL12
Genomic location for MRPL12
Band17q25.3Start81,703,367 bp[1]
End81,707,517 bp[1]
RNA expression pattern
PBB GE MRPL12 203931 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 17: 81.7 – 81.71 Mbn/a
PubMed search[2][3]
View/Edit HumanView/Edit Mouse

39S ribosomal protein L12, mitochondrial is a protein that in humans is encoded by the MRPL12 gene.[4][5][6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which forms homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10 protein form the L8 protein complex.[6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000262814 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Marty L, Fort P (Jun 1996). "A delayed-early response nuclear gene encoding MRPL12, the mitochondrial homologue to the bacterial translational regulator L7/L12 protein". J Biol Chem. 271 (19): 11468–76. doi:10.1074/jbc.271.19.11468. PMID 8626705.
  5. ^ Marty L, Taviaux S, Fort P (Jul 1997). "Expression and human chromosomal localization to 17q25 of the growth-regulated gene encoding the mitochondrial ribosomal protein MRPL12". Genomics. 41 (3): 453–7. doi:10.1006/geno.1997.4691. PMID 9169145.
  6. ^ a b "Entrez Gene: MRPL12 mitochondrial ribosomal protein L12".

Further reading[edit]