MRPL32

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MRPL32
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMRPL32, L32mt, MRP-L32, bMRP-59b, HSPC283, mitochondrial ribosomal protein L32
External IDsOMIM: 611839 MGI: 2137226 HomoloGene: 32711 GeneCards: MRPL32
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MRPL32
Genomic location for MRPL32
Band7p14.1Start42,932,376 bp[1]
End42,948,958 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031903

NM_029271

RefSeq (protein)

NP_114109

NP_083547

Location (UCSC)Chr 7: 42.93 – 42.95 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

39S ribosomal protein L32, mitochondrial is a protein that in humans is encoded by the MRPL32 gene.[4][5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000106591 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  5. ^ a b "Entrez Gene: MRPL32 mitochondrial ribosomal protein L32".

Further reading[edit]