Melatonin receptor 1A

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MTNR1A
Identifiers
AliasesMTNR1A, MEL-1A-R, MT1, Melatonin receptor 1A
External IDsOMIM: 600665 MGI: 102967 HomoloGene: 21207 GeneCards: MTNR1A
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for MTNR1A
Genomic location for MTNR1A
Band4q35.2Start186,533,655 bp[1]
End186,555,567 bp[1]
RNA expression pattern
PBB GE MTNR1A 221369 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005958

NM_008639

RefSeq (protein)

NP_005949

NP_032665

Location (UCSC)Chr 4: 186.53 – 186.56 MbChr 8: 45.07 – 45.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.[5][6]

Function[edit]

This gene encodes the MT1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.[6]

Ligands[edit]

  1. Melatonin – full agonist
  2. Afobazole – agonist
  3. Agomelatine – agonist

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168412 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054764 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (May 1995). "Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)". Genomics. 27 (2): 355–7. doi:10.1006/geno.1995.1056. PMID 7558006.
  6. ^ a b "Entrez Gene: MTNR1A melatonin receptor 1A".

Further reading[edit]