The Mississippi College Choctaws football team represents Mississippi College. The school's teams are known as the Choctaws. Its major rival is Millsaps College in nearby Jackson. After a more than 40-year hiatus, the two teams began meeting on the football field again in 2000. The rivalry is dubbed the Backyard Brawl.
The team won the Division II National Championship in 1989, however, Mississippi College's football tournament participation, along with its NCAA Division II national football championship, were vacated by the NCAA Committee on Infractions for recruiting violations.