Neurotensin receptor 1

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NTSR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNTSR1, NTR, Neurotensin receptor 1, neurotensin receptor 1 (high affinity), NTR1
External IDsOMIM: 162651 MGI: 97386 HomoloGene: 68261 GeneCards: NTSR1
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for NTSR1
Genomic location for NTSR1
Band20q13.33Start62,708,836 bp[1]
End62,762,771 bp[1]
RNA expression pattern
PBB GE NTSR1 207360 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002531

NM_018766

RefSeq (protein)

NP_002522

NP_061236

Location (UCSC)Chr 20: 62.71 – 62.76 MbChr 2: 180.5 – 180.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene.[5][6] For a crystal structure of NTS1, see pdb code 4GRV.

Function[edit]

Neurotensin receptor 1, also called NTR1, belongs to the large superfamily of G-protein coupled receptors and is considered a class-A GPCR. NTSR1 mediates multiple biological through modulation by neurotensin, such as low blood pressure, high blood sugar, low body temperature, antinociception, and regulation of intestinal motility and secretion.[6]

Ligands[edit]

  • ML314 – β-arrestin biased agonist[7]
  • Neurotensin (NT1)

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101188 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027568 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Laurent P, Clerc P, Mattei MG, Forgez P, Dumont X, Ferrara P, Caput D, Rostene W (May 1994). "Chromosomal localization of mouse and human neurotensin receptor genes". Mammalian Genome. 5 (5): 303–6. doi:10.1007/BF00389545. PMID 8075503. S2CID 30418560.
  6. ^ a b "Entrez Gene: NTSR1 neurotensin receptor 1 (high affinity)".
  7. ^ Peddibhotla S, Hedrick MP, Hershberger P, et al. (2013). "Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor". ACS Med Chem Lett. 4 (9): 846–851. doi:10.1021/ml400176n. PMC 3940307. PMID 24611085.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.