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Available structures
PDBHuman UniProt search: PDBe RCSB
AliasesP2RY11, P2Y11, purinergic receptor P2Y11
External IDsOMIM: 602697 HomoloGene: 130446 GeneCards: P2RY11
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for P2RY11
Genomic location for P2RY11
Band19p13.2Start10,111,693 bp[1]
End10,115,372 bp[1]
RNA expression pattern
PBB GE P2RY11 214546 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 10.11 – 10.12 Mbn/a
PubMed search[2]n/a
View/Edit Human

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.[3][4]

The product of this gene, P2Y11, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.[4]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000244165 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Communi D, Govaerts C, Parmentier M, Boeynaems JM (Jan 1998). "Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase". J Biol Chem. 272 (51): 31969–73. doi:10.1074/jbc.272.51.31969. PMID 9405388.
  4. ^ a b "Entrez Gene: P2RY11 purinergic receptor P2Y, G-protein coupled, 11".

Further reading[edit]

External links[edit]

  • "P2Y Receptors: P2Y11". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.