PDGFD

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PDGFD
Identifiers
AliasesPDGFD, IEGF, SCDGF-B, SCDGFB, MSTP036, platelet derived growth factor D
External IDsMGI: 1919035 HomoloGene: 11875 GeneCards: PDGFD
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for PDGFD
Genomic location for PDGFD
Band11q22.3Start103,907,189 bp[1]
End104,164,379 bp[1]
RNA expression pattern
PBB GE PDGFD gnf1h09263 s at fs.png

PBB GE PDGFD 219304 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033135
NM_025208

NM_027924
NM_001357397
NM_001357398

RefSeq (protein)

NP_079484
NP_149126

NP_082200
NP_001344326
NP_001344327

Location (UCSC)Chr 11: 103.91 – 104.16 MbChr 9: 6.17 – 6.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene.[5][6][7]

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170962 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032006 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Hamada T, Ui-Tei K, Imaki J, Miyata Y (Feb 2001). "Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein". Biochem Biophys Res Commun. 280 (3): 733–7. doi:10.1006/bbrc.2000.4187. PMID 11162582.
  6. ^ LaRochelle WJ, Jeffers M, Corvalan JR, Jia XC, Feng X, Vanegas S, Vickroy JD, Yang XD, Chen F, Gazit G, Mayotte J, Macaluso J, Rittman B, Wu F, Dhanabal M, Herrmann J, Lichenstein HS (Apr 2002). "Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancer". Cancer Res. 62 (9): 2468–73. PMID 11980634.
  7. ^ a b "Entrez Gene: PDGFD platelet derived growth factor D".

Further reading[edit]