PKD2L1

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PKD2L1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPKD2L1, PCL, PKD2L, PKDL, TRPP3, polycystin 2 like 1, transient receptor potential cation channel
External IDsOMIM: 604532 MGI: 1352448 HomoloGene: 22946 GeneCards: PKD2L1
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for PKD2L1
Genomic location for PKD2L1
Band10q24.31Start100,288,149 bp[1]
End100,330,264 bp[1]
RNA expression pattern
PBB GE PKD2L1 221061 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253837
NM_016112

NM_181422

RefSeq (protein)

NP_001240766
NP_057196

NP_852087

Location (UCSC)Chr 10: 100.29 – 100.33 MbChr 19: 44.15 – 44.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Polycystic kidney disease 2-like 1 protein also known as transient receptor potential polycystic 3 (TRPP3) is a protein that in humans is encoded by the PKD2L1 gene.[5]

Function[edit]

TRPP3 is a member of the polycystin protein family. TRPP3 contains multiple transmembrane domains, and cytoplasmic N- and C-termini. TRPP3 may be an integral membrane protein involved in cell-cell/matrix interactions. TRPP3 functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.[5]

Interactions[edit]

PKD2L1 has been shown to interact with TNNI3.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107593 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037578 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PKD2L1 polycystic kidney disease 2-like 1".
  6. ^ Li Q, Liu Y, Shen PY, Dai XQ, Wang S, Smillie LB, Sandford R, Chen XZ (June 2003). "Troponin I binds polycystin-L and inhibits its calcium-induced channel activation". Biochemistry. 42 (24): 7618–25. doi:10.1021/bi034210a. PMID 12809519.

Further reading[edit]