Poliovirus receptor-related 3

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NECTIN3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNECTIN3, CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3, PVRL3, nectin cell adhesion molecule 3
External IDsOMIM: 607147 MGI: 1930171 HomoloGene: 9162 GeneCards: NECTIN3
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for NECTIN3
Genomic location for NECTIN3
Band3q13.13Start111,070,071 bp[1]
End111,275,563 bp[1]
RNA expression pattern
PBB GE PVRL3 213325 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243286
NM_001243288
NM_015480

NM_021495
NM_021496
NM_021497

RefSeq (protein)

NP_001230215
NP_001230217
NP_056295

NP_067470
NP_067471
NP_067472

Location (UCSC)Chr 3: 111.07 – 111.28 MbChr 16: 46.39 – 46.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.[5]

Function[edit]

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][5]

Interactions[edit]

PVRL3 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000177707 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022656 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PVRL3 poliovirus receptor-related 3".
  6. ^ Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (April 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell–cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716.
  7. ^ Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (September 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene. 255 (2): 347–55. doi:10.1016/s0378-1119(00)00316-4. PMID 11024295.
  8. ^ Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M, Takai Y (February 2003). "Direct binding of cell polarity protein PAR-3 to cell–cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806.
  9. ^ Sakamoto Y, Ogita H, Komura H, Takai Y (2008). "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell–cell adhesion". J. Biol. Chem. 283 (1): 496–505. doi:10.1074/jbc.M704195200. PMID 17965016.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.