60S ribosomal protein L34

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RPL34
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRPL34, L34, ribosomal protein L34
External IDsOMIM: 616862 MGI: 3648994 HomoloGene: 137646 GeneCards: RPL34
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for RPL34
Genomic location for RPL34
Band4q25Start108,620,566 bp[1]
End108,630,412 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 4: 108.62 – 108.63 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L34 is a protein that in humans is encoded by the RPL34 gene.[4][5][6]

Function[edit]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Transcript variants derived from alternative splicing, alternative transcription initiation sites, and/or alternative polyadenylation exist; these variants encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109475 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A map of 75 human ribosomal protein genes". Genome Research. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  5. ^ Rommens JM, Durocher F, McArthur J, Tonin P, LeBlanc JF, Allen T, Samson C, Ferri L, Narod S, Morgan K (August 1995). "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091.
  6. ^ a b "Entrez Gene: RPL34 ribosomal protein L34".

Further reading[edit]

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L34