60S ribosomal protein L41

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RPL41
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRPL41, L41, ribosomal protein L41
External IDsOMIM: 613315 GeneCards: RPL41
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for RPL41
Genomic location for RPL41
Band12q13.2Start56,116,590 bp[1]
End56,117,967 bp[1]
RNA expression pattern
PBB GE RPL41 201492 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021104
NM_001035267

n/a

RefSeq (protein)

NP_001030344
NP_066927

n/a

Location (UCSC)Chr 12: 56.12 – 56.12 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

60S ribosomal protein L41 is a protein that in humans is encoded by the RPL41 gene.[3][4][5]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000229117 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Klaudiny J, von der Kammer H, Scheit KH (Oct 1992). "Characterization by cDNA cloning of the mRNA of a highly basic human protein homologous to the yeast ribosomal protein YL41". Biochem Biophys Res Commun. 187 (2): 901–6. doi:10.1016/0006-291X(92)91282-U. PMID 1326959.
  4. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  5. ^ a b "Entrez Gene: RPL41 ribosomal protein L41".

External links[edit]

Further reading[edit]