40S ribosomal protein S18

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RPS18
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRPS18, D6S218E, HKE3, KE-3, KE3, S18, ribosomal protein S18
External IDsOMIM: 180473 MGI: 98146 HomoloGene: 88764 GeneCards: RPS18
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for RPS18
Genomic location for RPS18
Band6p21.32Start33,272,075 bp[1]
End33,276,511 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022551

NM_011296
NM_138946

RefSeq (protein)

NP_072045

NP_035426

Location (UCSC)Chr 6: 33.27 – 33.28 MbChr 17: 33.95 – 33.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene.[5][6][7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S13P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S13) is involved in the binding of fMet-tRNA, and thus, in the initiation of translation. This gene is an ortholog of mouse Ke3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References[edit]

  1. ^ a b c ENSG00000096150, ENSG00000231500, ENSG00000235650, ENSG00000223367, ENSG00000227794 GRCh38: Ensembl release 89: ENSG00000226225, ENSG00000096150, ENSG00000231500, ENSG00000235650, ENSG00000223367, ENSG00000227794 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008668 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chassin D, Bellet D, Koman A (Mar 1993). "The human homolog of ribosomal protein S18". Nucleic Acids Res. 21 (3): 745. doi:10.1093/nar/21.3.745. PMC 309181. PMID 8441687.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b "Entrez Gene: RPS18 ribosomal protein S18".

Further reading[edit]

External links[edit]

  • Overview of all the structural information available in the PDB for UniProt: P62269 (40S ribosomal protein S18) at the PDBe-KB.