40S ribosomal protein S4, Y isoform 1

From Wikipedia, the free encyclopedia
  (Redirected from RPS4Y1)
Jump to navigation Jump to search
Available structures
PDBOrtholog search: PDBe RCSB
AliasesRPS4Y1, RPS4Y, S4, ribosomal protein S4, Y-linked 1, ribosomal protein S4 Y-linked 1
External IDsOMIM: 470000 MGI: 98158 HomoloGene: 133576 GeneCards: RPS4Y1
Gene location (Human)
Y chromosome (human)
Chr.Y chromosome (human)[1]
Y chromosome (human)
Genomic location for RPS4Y1
Genomic location for RPS4Y1
BandYp11.2Start2,841,602 bp[1]
End2,932,000 bp[1]
RNA expression pattern
PBB GE RPS4Y1 201909 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr Y: 2.84 – 2.93 MbChr X: 102.18 – 102.19 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

40S ribosomal protein S4, Y isoform 1 is a protein that in humans is encoded by the RPS4Y1 gene.[5][6][7]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene, RPS4Y2 and the ribosomal protein S4, X-linked (RPS4X). The 3 isoforms encoded by these genes are not identical, but appear to be functionally equivalent.[8] Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129824 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031320 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: RPS4Y1 ribosomal protein S4, Y-linked 1".
  6. ^ Fisher EM, Beer-Romero P, Brown LG, Ridley A, McNeil JA, Lawrence JB, Willard HF, Bieber FR, Page DC (December 1990). "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome". Cell. 63 (6): 1205–18. doi:10.1016/0092-8674(90)90416-C. PMID 2124517.
  7. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  8. ^ Andrés O, Kellermann T, López-Giráldez F, Rozas J, Domingo-Roura X, Bosch M (2008). "RPS4Y gene family evolution in primates". BMC Evol. Biol. 8: 142. doi:10.1186/1471-2148-8-142. PMC 2397393. PMID 18477388.

Further reading[edit]