Ribosomal protein s6

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ribosomal protein S6
NCBI gene6194
Other data
LocusChr. 9 p21

Ribosomal protein S6 (rpS6) is a component of the 40S ribosomal subunit and is therefore thought to be involved in regulating translation. While the true function of rpS6 is currently under investigation, mouse model studies have shown that it is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.[1]

Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate rpS6 and that S6K1 and S6K2 predominate this function.

Pathways leading to the induction of human rpS6 phosphoryation been found to enhance Interleukin 8 IL-8 protein synthesis. This mechanism is dependent on A/U-rich proximal sequences (APS) found in the 3'UTR of IL-8 immediately after the stop codon.[2]


  1. ^ Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, Dor Y, Zisman P, Meyuhas O (September 2005). "RRibosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis". Genes Dev. 19 (18): 2199–2211. doi:10.1101/gad.351605. PMC 1221890. PMID 16166381.
  2. ^ Ang Z, Abdi Gunawan Koen R, Er JZ, Lee LT, Tam Kit Chung J, Guo H, Ding JL (2019). "Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation". PLoS Genet. 15 (4): e1008077. doi:10.1371/journal.pgen.1008077. PMC 6476525. PMID 30969964.

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