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AliasesSLC22A11, OAT4, hOAT4, solute carrier family 22 member 11
External IDsOMIM: 607097 HomoloGene: 81863 GeneCards: SLC22A11
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SLC22A11
Genomic location for SLC22A11
Band11q13.1Start64,555,690 bp[1]
End64,572,875 bp[1]
RNA expression pattern
PBB GE SLC22A11 220100 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 11: 64.56 – 64.57 Mbn/a
PubMed search[2]n/a
View/Edit Human

Solute carrier family 22 member 11 is a protein that in humans is encoded by the SLC22A11 gene.[3][4][5][6]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus.[6]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000168065 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H (Mar 2000). "Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta". J Biol Chem. 275 (6): 4507–12. doi:10.1074/jbc.275.6.4507. PMID 10660625.
  4. ^ Zhou F, Xu W, Hong M, Pan Z, Sinko PJ, Ma J, You G (Feb 2005). "The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4". Mol Pharmacol. 67 (3): 868–76. doi:10.1124/mol.104.007583. PMID 15576633. S2CID 7477352.
  5. ^ Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A (Jan 2007). "Human renal organic anion transporter 4 operates as an asymmetric urate transporter". J Am Soc Nephrol. 18 (2): 430–9. doi:10.1681/ASN.2006040415. PMID 17229912.
  6. ^ a b "Entrez Gene: SLC22A11 solute carrier family 22 (organic anion/cation transporter), member 11".

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.