Mitochondrial uncoupling protein 4

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  (Redirected from SLC25A27)
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AliasesSLC25A27, solute carrier family 25, member 27, UCP4, solute carrier family 25 member 27
External IDsOMIM: 613725 MGI: 1921261 HomoloGene: 12523 GeneCards: SLC25A27
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for SLC25A27
Genomic location for SLC25A27
Band6p12.3Start46,652,915 bp[1]
End46,678,190 bp[1]
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 6: 46.65 – 46.68 MbChr 17: 43.64 – 43.67 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.[5][6][7]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are detected only in brain tissue and are specifically modulated by various environmental conditions.[7] Recently, the proton transport activity of UCP4 has also been shown to be activated by fatty acids and inhibited by purine nucleotides.[8] In addition, reconstituted UCP4 exhibited a distinct conformation, compared to other UCPs in the family.[9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153291 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023912 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao W, Yu XX, Zhong A, Li W, Brush J, Sherwood SW, Adams SH, Pan G (Mar 1999). "UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells". FEBS Lett. 443 (3): 326–30. doi:10.1016/S0014-5793(98)01713-X. PMID 10025957. S2CID 314036.
  6. ^ Jezek P, Urbankova E (Jun 2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life. 49 (1): 63–70. doi:10.1080/713803586. PMID 10772343. S2CID 8541209.
  7. ^ a b "Entrez Gene: SLC25A27 solute carrier family 25, member 27".
  8. ^ Hoang T, Smith MD, Jelokhani-Niaraki M (2012). "Toward Understanding the Mechanism of Ion Transport Activity of Neuronal Uncoupling Proteins UCP2, UCP4, and UCP5". Biochemistry. 51 (19): 4004–14. doi:10.1021/bi3003378. PMID 22524567.
  9. ^ Ivanova M, Hoang T, McSorly FR, Krnac G, Smith MD, Jelokhani-Niaraki M (2010). "A comparative study on conformation and ligand binding of the neuronal uncoupling proteins". Biochemistry. 49 (3): 512–21. doi:10.1021/bi901742g. PMID 20000716.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.