Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.
The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles. In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala. Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway. Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000115194 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029151 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Solute carrier family 30 (zinc transporter), member 3".
- ^ Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD (February 1999). "Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1716–21. doi:10.1073/pnas.96.4.1716. PMC 15571. PMID 9990090.
- ^ Sindreu C, Storm DR (2011). "Modulation of neuronal signal transduction and memory formation by synaptic zinc". Frontiers in Behavioral Neuroscience. 5: 68. doi:10.3389/fnbeh.2011.00068. PMC 3211062. PMID 22084630.
- ^ Mott DD, Dingledine R (February 2011). "Unraveling the role of zinc in memory". Proceedings of the National Academy of Sciences of the United States of America. 108 (8): 3103–4. doi:10.1073/pnas.1100323108. PMC 3044369. PMID 21321213.
- ^ Patrushev N, Seidel-Rogol B, Salazar G (2012). "Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells". PLOS ONE. 7 (3): e33211. doi:10.1371/journal.pone.0033211. PMC 3299759. PMID 22427991.