TAS2R4

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TAS2R4
Identifiers
AliasesTAS2R4, T2R4, taste 2 receptor member 4
External IDsOMIM: 604869 MGI: 2681210 HomoloGene: 49480 GeneCards: TAS2R4
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for TAS2R4
Genomic location for TAS2R4
Band7q34Start141,778,442 bp[1]
End141,780,819 bp[1]
RNA expression pattern
PBB GE TAS2R4 221392 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016944

NM_020502

RefSeq (protein)

NP_058640

NP_065248

Location (UCSC)Chr 7: 141.78 – 141.78 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.[4][5][6]

Function[edit]

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[6]

Ligands[edit]

Ligands listed in BitterDB include quinine, parthenolide, denatonium, some non-sugar sweeteners including sucralose and stevioside, and several oligopeptides.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127364 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
  5. ^ Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (Apr 2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
  6. ^ a b "Entrez Gene: TAS2R4 taste receptor, type 2, member 4".
  7. ^ "hTAS2R4 - Taste receptor type 2 member 4". BitterDB. The Hebrew University of Jerusalem.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.