TBCA

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TBCA
Protein TBCA PDB 1h7c.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTBCA, tubulin folding cofactor A
External IDsOMIM: 610058 MGI: 107549 HomoloGene: 3388 GeneCards: TBCA
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TBCA
Genomic location for TBCA
Band5q14.1Start77,691,166 bp[1]
End77,868,780 bp[1]
RNA expression pattern
PBB GE TBCA 203667 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004607
NM_001297738
NM_001297740

NM_009321

RefSeq (protein)

NP_001284667
NP_001284669
NP_004598

NP_033347

Location (UCSC)Chr 5: 77.69 – 77.87 MbChr 13: 94.79 – 94.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.[5][6][7]

The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171530 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042043 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
  6. ^ Tian G, Huang Y, Rommelaere H, Vandekerckhove J, Ampe C, Cowan NJ (Sep 1996). "Pathway leading to correctly folded beta-tubulin". Cell. 86 (2): 287–96. doi:10.1016/S0092-8674(00)80100-2. PMID 8706133.
  7. ^ a b "Entrez Gene: TBCA tubulin folding cofactor A".

Further reading[edit]